A9.2 The Phosphoinositide 3-Kinase Pathway Regulates Fibroblast-Like Synoviocytes Invasion

Phosphoinositide 3-Kinase d Regulates Migration and Invasion of Synoviocytes in Rheumatoid Arthritis

Phosphoinositide 3-kinase δ regulates migration and invasion of synoviocytes in rheumatoid arthritis.

Cartilage destruction mediated by invasive fibroblast-like synoviocytes (FLS) plays a central role in pathogenesis of rheumatoid arthritis (RA). Increased cell migration and degradation of extracellular matrix are fundamental to these processes. The class I PI3Ks control cell survival, proliferation, and migration, which might be involved in cartilage damage in RA. PI3Kδ isoform was recently id...

Rheumatoid Arthritis Migration and Invasion of Synoviocytes in Regulates δ Phosphoinositide 3-Kinase

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation

BACKGROUND The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC)gamma1. Here we investigated the basic FGF (FGF-2)-mediated activation of these enzymes ...

NF-kB Regulates VCAM-1 Expression on Fibroblast-Like Synoviocytes